Ubuntu: sometimes after a suspend or two, I lose sound. Sometimes the mouse stops working.
Solution: rmmod the appropriate driver, then re-modprobe it.
For mouse, on my computer:
sudo rmmod psmouse sudo modprobe psmouse
(on Ubuntu Karmic, on an eeepc 901).
For sound, its a bit trickier, but it’s something like:
pulseaudio -k sudo rmmod snd_hda_intel sudo modprobe snd_hda_intel pulseaudio -D
.. with maybe a couple of extra rmmod’s first, in order to remove snd_pcm, perhaps also snd_timer, maybe snd.